Mark Hochstrasser

Mark Hochstrasser is the Eugene Higgins Professor of Molecular Biophysics & Biochemistry and Professor of Molecular, Cellular & Developmental Biology at Yale University. He is affiliated with the Yale Cancer Center and the School of Medicine’s Biological and Biomedical Sciences Program. His research interests include biochemistry, cell growth processes, Drosophila, enzymes, genetics, microscopy, immunoelectron techniques, molecular biology, mutant chimeric proteins, proteasome endopeptidase complex, Saccharomyces cerevisiae, scrub typhus, sumoylation, transcription factors, ubiquitin, and Wolbachia. His work focuses on the ubiquitin system, proteasome assembly, and interactions with endosymbiotic bacteria.

Mark Hochstrasser is a researcher at Yale University specializing in the ubiquitin-proteasome system and its role in intracellular protein degradation. His work explores the mechanisms of ubiquitin-dependent protein degradation, the function of ubiquitin-like proteins, and the regulation of proteasomal activity. Hochstrasser's research also investigates deubiquitinating enzymes, unconventional ubiquitin chains, and the molecular architecture of the eukaryotic proteasome. His studies contribute to understanding the diversity of degradation signals and the evolution of ubiquitin-like protein-conjugation systems. His work has significant implications for elucidating the role of ubiquitin in cellular processes and disease.