Zhengfan JIANG

Zhengfan JIANG is a Professor in the School of Life Sciences at Peking University. His research focuses on immunology, particularly the mechanisms of innate immune signaling and the role of cyclic nucleotides in antiviral responses. He has published extensively in leading journals such as Immunity, Nature Cell Biology, and Cell Research. JIANG's work includes studies on the STING pathway, cGAS-STING signaling, and the regulation of immune responses by manganese and other factors. He has held positions at Peking-Tsinghua Center for Life Sciences and The Scripps Research Institute, and his laboratory is based at Peking University. His contact information is available at jiangzf@pku.edu.cn, and his lab website is https://www.bio.pku.edu.cn/en/index/index/by_speciality_detail/cid/71/id/50.html.

Zhengfan Jiang's research focuses on the molecular mechanisms underlying innate immune signaling and host defense against pathogens. His work explores the role of metal ions, particularly manganese, in modulating immune responses through pathways such as cGAS-STING and STING-mediated autophagy. Jiang's studies also investigate Toll-like receptor (TLR) signaling, including TLR3 and TLR4, and their interactions with adaptor proteins like MyD88 and IRAK. Additionally, he examines the role of ERIS, CD14, and other components in innate immunity. His research highlights the importance of metalloimmunology in antiviral and antitumor immunity, with implications for immunotherapy.