Jiazhi HU

Jiazhi HU is a Professor at Peking University, School of Life Sciences, where they lead research in immunology and immunology experiments. Their work primarily focuses on immune cells from mice and humans, investigating the relationship between DNA replication, DNA damage, DNA metabolism, genome stability, and tumor occurrence in the complex chromatin environment of mammals. They also explore changes in lymphocyte function and associated DNA metabolism changes over time and across different tissues during the aging process. Additionally, they study the development and maturation mechanisms of antibodies and utilize synthetic biology techniques to modify cells, promoting antibody production and evolution. HU's research has been published in prominent journals such as Science, Nature Genetics, and Nature Communications.

Jiazhi Hu is a professor at Peking University, specializing in genome stability, DNA metabolism, and antibody diversification. His research explores mechanisms of DNA double-stranded breaks, genomic instability, and DNA repair processes. Hu's work includes the development of high-throughput methods for detecting DNA damage and analyzing repair outcomes, as well as investigations into CRISPR/Cas9-mediated genome editing and its applications in preventing chromosomal translocations. His studies also focus on the role of chromosomal loop domains in antigen receptor gene recombination and the regulation of DNA repair pathways. Hu's research contributes to understanding how transcription and replication dynamics influence genome integrity and how these processes are modulated in immune system development and disease.