Jian LU

Jian LU is a Professor at Peking University's School of Life Sciences. His research integrates RNA biology, molecular evolution, and computational methods to study translation regulation mechanisms and their evolutionary patterns. His work explores how RNA regulatory elements, such as uORF, RNA editing, and non-coding RNAs, influence gene expression and adaptive evolution. He also investigates the role of RNA biology in environmental adaptation and RNA virus evolution, with applications in vaccine design and disease mechanisms. LU's laboratory combines experimental techniques and computational analysis, utilizing Drosophila models, in vitro systems, and deep learning models to advance basic life sciences and biotechnology.

Jian Lu's research focuses on genomics, small RNA, population genetics, and evolutionary biology. His work explores the evolution of genes and genomes, particularly in Drosophila, and investigates the role of small RNA in gene regulation and adaptation. Lu examines the impact of microRNA on gene expression variation and the evolutionary dynamics of RNA elements such as uORFs and tsRNAs. His studies also address the genetic basis of domestication in rice and the evolutionary forces shaping genome-wide patterns of variation. Through population genetics approaches, Lu investigates the accumulation of deleterious mutations and adaptive evolution in diverse species.