Sarah Slavoff

Sarah Slavoff is an Associate Professor of Chemistry and of Molecular Biophysics and Biochemistry at Yale University, affiliated with the Department of Chemistry. Her research focuses on Chemical Biology and Biophysical Chemistry, with an emphasis on studying the functions of small open reading frames and their encoded microproteins. She is the Director of Undergraduate Studies and a member of the Institute of Biomolecular Design and Discovery. Her work involves interdisciplinary methods such as mass spectrometry-based proteomics, cellular imaging, and chemical synthesis to explore the roles of these microproteins in human cells and disease. Slavoff joined Yale's faculty in 2014 and maintains a laboratory website at https://chem.yale.edu/profile/sarah-slavoff.

Sarah Slavoff is a chemical biologist at Yale University whose research focuses on the discovery and functional characterization of microproteins and small open reading frame (sORF)-encoded polypeptides. Her work explores the roles of these proteins in cellular processes such as RNA decapping, DNA repair, and immune responses. By employing proteomic and chemoproteomic approaches, she investigates how non-canonical open reading frames contribute to biological functions. Her studies also examine the impact of alternative start codons and the regulation of translation under stress conditions. Through these efforts, Slavoff contributes to expanding the understanding of the human proteome and its implications in health and disease.