Craig Crews

Craig Crews is the John C. Malone Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry and Pharmacology at Yale University. He is affiliated with the Department of Chemistry and holds a faculty position since 1995. His research focuses on Chemical Biology and Organic Chemistry. Crews is the Executive Director of the Yale Center for Molecular Discovery. His work includes the development of Proteolysis Targeting Chimera (PROTAC), a technology that enables the intracellular destruction of target proteins. His research has explored various targets, including kinases, transcription factors, and epigenetic readers, using multiple E3 ubiquitin ligases. He is also recognized for his contributions to the field through numerous awards and honors.

Craig Crews is a chemical biologist at Yale University whose research focuses on the development of novel therapeutic strategies through targeted protein degradation. His work explores the design and application of PROTACs (PROteolysis TArgeting Chimeras), which are small-molecule compounds that induce the degradation of specific proteins by recruiting E3 ubiquitin ligases. Crews has contributed significantly to understanding the mechanisms of PROTACs and their potential in drug discovery, particularly for oncology and inflammatory diseases. His research also includes the study of natural products and their interactions with cellular targets, highlighting the therapeutic potential of traditional medicines.