Anna M. Pyle

Anna M. Pyle is the Sterling Professor of Molecular, Cellular and Developmental Biology and Professor of Chemistry at Yale University. She is affiliated with the Department of Chemistry and holds a joint appointment in Molecular, Cellular and Developmental Biology. Her research focuses on Chemical Biology and Biophysical Chemistry, with an emphasis on RNA structure and RNA recognition by protein enzymes. Her work explores the architectural features of large RNA molecules, such as self-splicing introns and noncoding RNAs, and the mechanisms by which RNA is recognized and remodeled by ATP-dependent enzymes. She is also involved in studying RNA-dependent ATPases and their roles in viral replication and host immune responses. Her research combines experimental biochemistry, crystallography, and computational methods to advance understanding of RNA structure and function.

Anna Marie Pyle is a researcher at Yale University specializing in RNA structure, function, and interactions. Her work explores the molecular mechanisms underlying RNA recognition, unwinding, and structural stabilization. Pyle's research includes the study of RNA helicases, RNA-protein interactions, and the role of metal ions in RNA structure and catalysis. She has investigated the structural and functional properties of RNA motifs, RNA-binding proteins, and the implications of RNA tertiary structure in biological processes. Her research also extends to the analysis of RNA in viral infections, including the molecular interactions of SARS-CoV-2 and the role of innate immune responses. Pyle's contributions span both fundamental RNA biology and applied research in virology.