Rajendra Karki

Rajendra Karki is an Assistant Professor in the Department of BIO at Seoul National University. His research focuses on host defense against infectious diseases, particularly the role of inflammasome activation and cell death in clearing pathogens such as bacteria, fungi, and viruses. He investigates how innate immune sensors, such as AIM2 and NLRP3, recognize specific pathogens and contribute to immune responses. His work also explores cytokine storms and their role in disease pathogenesis, as well as the connection between cell death, metabolic diseases, and cancer. Karki's research utilizes cutting-edge technologies to understand immune mechanisms and their implications for therapeutic strategies.

Rajendra Karki's research focuses on immunology, particularly the molecular mechanisms of inflammatory responses and cell death pathways in infectious diseases. His work explores the roles of inflammasomes, such as AIM2 and NLRP3, in sensing pathogens and triggering immune responses. He investigates how cytokine storms and inflammatory cell death, including pyroptosis, apoptosis, and necroptosis, contribute to disease progression. His studies also examine the interplay between immune sensors like ZBP1, DDX3X, and ADAR1 in modulating host defense and tumorigenesis. Karki's research highlights the significance of innate immunity in combating viral infections, such as SARS-CoV-2, and its implications for therapeutic strategies.