Adrian Smith

Professor Adrian Smith is a member of the Department of Biology at the University of Oxford. His research focuses on understanding the basis of immunity to infectious challenge, particularly in birds and mammals. His work explores immune mechanisms in the gut and the role of T lymphocytes in protective immunity. Current projects include the comparative biology of pattern recognition receptors, TCRαβ and TCRγδ T cell biology, parasite genetics, and mechanisms of immunity against parasitic protozoa and bacterial pathogens. He also holds Jenner Investigator status and received the Daiwa Foundation Lord Adrian Prize in 2007 for studies on enteric T cell function.

Adrian L Smith is a researcher in Immunology, Infectious Disease, and Comparative Immunology, with a focus on avian and mammalian immune responses to pathogens. His work explores the molecular mechanisms of immune defense against infections such as Salmonella enterica and Eimeria, with an emphasis on cytokine and chemokine responses, Toll-like receptor function, and host-pathogen interactions. He investigates how genetic variation, such as allelic differences in TLR4, influences susceptibility to infections and how immune cell subsets, like heterophils and γδ T cells, contribute to disease resistance. His research also addresses the impact of microbiota on host immunity and disease outcomes in farm animals.