Eric Kool

Eric Kool is the George A. and Hilda M. Daubert Professor of Chemistry in the Department of Chemistry at Stanford University. His research focuses on the Chemistry-Biology Interface and Organic Chemistry. Kool received his Ph.D. in Chemistry from Columbia University and completed postdoctoral work in nucleic acids chemistry at Caltech. He joined Stanford in 1999 after teaching at the University of Rochester. His lab uses chemical tools to study nucleic acids and their interacting enzymes, with an emphasis on molecular design, synthesis, and analysis of structure and function in both test tubes and living systems. Recent interests include chemical tools for RNA structure mapping, RNA stabilization, and DNA repair pathway probes.

Eric T. Kool is a researcher in Organic Chemistry, Chemical Biology, and Nucleic Acids at Stanford University. His work focuses on understanding RNA regulatory mechanisms, DNA replication, and the structural properties of nucleic acids. Kool's research explores the role of hydrogen bonding, base stacking, and steric effects in DNA and RNA interactions. He investigates bioconjugation methods, such as oximes and hydrazones, and develops shape analogs for nucleobases to study DNA replication fidelity. His studies also include RNA SHAPE analysis, rolling circle DNA synthesis, and the design of fluorescent nucleobases for studying nucleic acid dynamics. Kool's contributions span the development of tools for studying DNA and RNA structure and function.