Scott Dixon

Scott Dixon is a Lecturer in the Department of Biology at Stanford University. His research focuses on investigating cell death pathways using chemical biology and functional genomics. Dixon's work integrates techniques such as small molecule and proteomic screening, biochemical analysis of protein function, and model organism genetics. His research program explores the interaction between intracellular metabolism and cell death, with a particular emphasis on understanding the role of genetic networks in regulating cell viability. Dixon's academic background includes a B.Sc. in Behavioral Neuroscience from Laurentian University and a Ph.D. in Molecular and Medical Genetics from the University of Toronto. He has previously studied genetic networks in the nematode worm Caenorhabditis elegans and the single-celled eukaryotes S. cerevisiae and S. pombe. His postdoctoral research demonstrated that the small molecule erastin inhibits the membrane cystine/glutamate transporter system xc-, depletes the cell of glutathione, and activates a novel iron-dependent, oxidative cell death pathway termed ferroptosis.

Scott Dixon is a Professor of Biology at Stanford University, specializing in ferroptosis, cell death, and metabolism. His research explores the molecular mechanisms of ferroptosis, an iron-dependent form of nonapoptotic cell death, and its connections to redox biology and disease. Dixon's work investigates how metabolic pathways, such as lipid homeostasis and cystine–glutamate exchange, regulate ferroptosis and its role in cancer and other pathologies. His studies also examine the interplay between iron, reactive oxygen species, and cell death, as well as the function of proteins like FSP1 and GPX4 in inhibiting ferroptosis. His research has implications for understanding and targeting metabolic disorders and cancer.