Barbara Imperiali

Barbara Imperiali is a Professor in the Department of Chemistry at the Massachusetts Institute of Technology. Her research focuses on protein structure, function, and design, employing a multidisciplinary approach that includes synthesis, spectroscopy, molecular modeling, enzymology, and molecular biology. Her work addresses fundamental problems at the interface of chemistry and biology, particularly in the areas of protein modification and the study of enzyme-catalyzed glycosylation. The Imperiali group investigates the biological significance of N-linked glycosylation and develops chemical tools for studying complex biological systems, including fluorescent and luminescent probes for analyzing protein phosphorylation and signal transduction processes.

Barbara Imperiali is a Professor of Biology and Chemistry at the Massachusetts Institute of Technology, with research interests spanning chemical biology, biophysics, biochemistry, glycobiology, and microbiology. Her work explores the structural and functional roles of glycosylation in proteins, the design of fluorescent chemosensors for metal ions, and the development of tools for studying protein dynamics and interactions. She has published extensively on topics such as N-linked glycosylation, protein oligomerization, and the use of solvatochromic fluorophores in biological systems. Her research bridges fundamental biochemical processes with applications in biotechnology and molecular imaging.