Jiyong Hong

Jiyong Hong is a Professor of Chemistry at Duke University, affiliated with the Chemistry department in the Trinity College of Arts & Sciences. His research focuses on using chemical tools, particularly small molecules, to study biological signaling pathways. His work involves synthesizing natural products, screening small molecule libraries, and exploring their modes of action to identify novel targets for drug design. Hong's research also includes developing synthetic strategies to access molecular complexity and structural diversity. He is an Associate Chair of Chemistry and an Associate Professor of Pharmacology and Cancer Biology. Additionally, he is a member of the Duke Cancer Institute.

Jiyong Hong is a researcher at Duke University with a focus on chemical biology and natural product synthesis. His work explores the structural and functional aspects of natural products, particularly their roles in biological systems and therapeutic applications. Hong's research includes the total synthesis of complex molecules such as largazole, a histone deacetylase inhibitor, and the elucidation of their mechanisms of action. He also investigates the chemical logic behind enzyme inhibition, such as MraY, which is critical for bacterial cell wall synthesis. His studies highlight the importance of natural product diversity in drug discovery and the development of small molecules targeting specific biological processes, such as tumor cell motility and cancer therapy.