Emily R. Derbyshire

Emily R. Derbyshire is the Eads Family Professor in the Department of Chemistry at Duke University. Her research focuses on malaria parasite biology, utilizing chemical tools and biological methods to identify druggable targets. Her work integrates chemical biology, molecular biology, and biochemistry to explore biological pathways and develop small molecules with therapeutic potential. Derbyshire is also a Professor of Molecular Genetics and Microbiology and Cell Biology at Duke. Her recent publications include studies on γ-glutamyl transferase activity and Plasmodium falciparum Hsp90, highlighting her contributions to antimalarial drug discovery.

Emily R Derbyshire is a Professor at Duke University specializing in Chemical Biology, Infectious Disease, and Drug Discovery. Her research focuses on understanding the molecular mechanisms of nitric oxide signaling and its role in disease, particularly in the context of infectious diseases such as malaria. She investigates the structure and function of soluble guanylate cyclase, a key enzyme in nitric oxide signaling, and explores its potential as a therapeutic target. Derbyshire's work also includes the development of novel antimalarial compounds, targeting liver-stage parasites and exploring chemical scaffolds that disrupt Plasmodium biology. Her research integrates biochemical, structural, and chemoproteomic approaches to identify and validate drug targets for infectious diseases.