Edwin Alfonzo

Edwin Alfonzo is an Assistant Professor of Chemistry at Duke University, affiliated with the Chemistry department. His research focuses on biocatalysis, utilizing enzymes to catalyze chemical reactions and expanding their functional scope through organic chemistry, protein engineering, enzymology, and data science. Alfonzo's work explores new-to-nature transformations and the development of catalysts for advanced chemical synthesis. His recent publications include studies on biocatalytic synthesis and enzymatic nitrogen incorporation. He is also involved in research grants aimed at unlocking new chemistries in enzymes for synthesizing bioactive molecules.

Edwin Alfonzo is a researcher at Duke University whose work focuses on the development of catalytic methods for the synthesis of complex organic molecules. His research integrates photoredox catalysis, enzymatic transformations, and biocatalytic approaches to enable the efficient and selective formation of carbon-carbon and carbon-heteroatom bonds. Alfonzo's work includes the design of novel photoredox catalysts for generating carbonyl ylides, as well as the engineering of enzymes for nitrogen insertion and cyanomethylation reactions. His studies also explore the application of biocatalysts in the synthesis of noncanonical amino acids and α-amino esters. These efforts aim to expand the toolkit for organic synthesis and enable the creation of structurally diverse natural products.