Hiroki Oguri

Hiroki Oguri is a Professor at The University of Tokyo, Department of Chemistry. His research focuses on natural products chemistry, synthetic organic chemistry, chemical biology, and supramolecular chemistry. His current work involves the biogenetically inspired synthesis of skeletally diverse natural products and the generation of functional mid-sized molecules. He is also exploring the interface of natural products and supramolecular chemistry, utilizing the molecular recognition capabilities of natural products. His research aims to develop chemical assembly lines and chemo-enzymatic processes for rapid access to natural products and their variants, with applications in chemical genetics and medicinal research.

Hiroki Oguri is a researcher specializing in natural product chemistry, chemical biology, and supramolecular chemistry. His work focuses on the total synthesis of complex natural products such as ciguatoxin CTX3C and indole alkaloids, as well as the biosynthesis of antitumor nonribosomal peptides. Oguri's research integrates synthetic methods with biological insights to explore the structural diversity and functional mechanisms of natural products. He has contributed to the elucidation of the absolute configuration of ciguatoxin and the biosynthetic pathways of polyether compounds like lasalocid A. His studies also involve the heterologous expression of biosynthetic enzymes and the development of chemoenzymatic approaches for molecular diversification.