Regular biography
Nancy M. Bonini is a Professor of Biology Secondary Faculty at the University of Pennsylvania, Department of Biology. She is affiliated with the Perelman School of Medicine as Secondary Faculty in Cell & Developmental Biology and Neuroscience. Her research interests include neurobiology, behavior, physiology, genetics, epigenetics, and genomics. Her laboratory uses Drosophila melanogaster to study genetic modulation of neurodegenerative and neurological diseases, focusing on the role of polyglutamine expansions in conditions such as Huntington's disease. She has contributed to understanding the mechanisms of neural degeneration and is involved in exploring the interplay between aging, environmental factors, and disease progression. Her work has been recognized through various awards and affiliations, including membership in the National Academy of Sciences and the American Academy of Arts and Sciences.
Scholar-generated biography
Nancy M Bonini is a researcher at the University of Pennsylvania whose work focuses on neurodegenerative diseases using Drosophila as a model organism. Her research explores the molecular mechanisms underlying conditions such as Parkinson's disease, amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease. Bonini's studies investigate the role of proteins like α-synuclein, polyglutamine expansions, and TDP-43 in neurodegeneration, emphasizing their impact on cellular processes such as ER-Golgi traffic, axonal transport, and epigenetic regulation. Her work also examines the therapeutic potential of molecular chaperones, heat shock proteins, and epigenetic modulators in mitigating disease progression. Bonini's research highlights the importance of genetic and environmental factors in neurodegenerative disorders.