Scott Biering

Scott Biering is an Assistant Professor in the Department of BIO at the University of California, San Diego. His research focuses on viral pathogenesis, particularly host-pathogen interactions at the interface of physiological barriers. His work explores how viruses disrupt host barriers and investigates strategies to block viral pathogenesis. Biering's research includes studies on flaviviruses and SARS-CoV-2, with an emphasis on understanding mechanisms of barrier dysfunction and developing therapeutic approaches. He joined UCSD in 2023 after completing postdoctoral studies at the University of California, Berkeley, where he investigated mechanisms of flavivirus and coronavirus pathogenesis.

Scott B Biering's research focuses on virology, autophagy, immunology, microbiology, and cell biology. His work explores how viral proteins, such as flavivirus NS1 and Nipah virus attachment glycoprotein, induce endothelial dysfunction, vascular leak, and barrier disruption through mechanisms involving integrins, TGF-β signaling, and GSK-3β. He investigates the role of autophagy in targeting viral replication complexes and immune responses, including the function of IFNG-inducible GTPases and ubiquitin-like conjugation systems. His studies also address host-virus interactions, such as mucin modulation of SARS-CoV-2 infection and the use of CRISPR screens to identify host factors. Additionally, he examines therapeutic strategies, including ASO-based treatments and antiviral drug combinations, to combat viral diseases.