Lydia Lynch

Lydia Lynch is a Professor of Molecular Biology and Ludwig Princeton Branch at Princeton University, affiliated with the Department of BIO. Her research focuses on immunometabolism, specifically the interaction between the immune and metabolic systems. The Lynch Lab investigates how innate immune cells regulate systemic metabolism and how altered metabolism affects immune cell function. Using models such as obesity, diabetes, and the tumor microenvironment, the lab explores immunometabolic interactions in vivo. Lynch's work bridges organismal and cell-intrinsic levels of immunometabolism, employing advanced techniques to study these phenomena. She has held significant postdoctoral positions at institutions including St. Vincent’s University Hospital, Harvard Medical School, and Brigham and Women’s Hospital, where she developed her independent research program.

Lydia Lynch's research focuses on immunology and obesity, with an emphasis on understanding the interplay between the immune system and adipose tissue in metabolic disorders. Her work explores how immune cells, such as natural killer (NK) cells, invariant NKT cells, and γδ T cells, contribute to obesity-related inflammation and metabolic disease. She investigates metabolic reprogramming of immune cells in obesity, including the role of glucose metabolism, lactate accumulation, and cytokine production in modulating immune responses. Her studies also examine the impact of adipose tissue inflammation on type 2 diabetes and the potential therapeutic implications of targeting immune pathways in metabolic conditions.