Regular biography
Akane Kawamura is a Visiting Professor in the Department of Chemistry at the University of Oxford. Her research interests include the molecular mechanisms of biological processes, with a focus on epigenetic modifications, protein-protein interactions, and the development of chemical tools. She employs biochemical, biophysical, and cell-based approaches to study proteins involved in epigenetic regulation and inflammation. Her work bridges chemistry, biology, and medicine, often through collaborative projects. Kawamura's research explores histone modifiers, DNA modifiers, and chemokine signaling, with an emphasis on creating chemical probes and understanding their roles in health and disease.
Scholar-generated biography
Akane Kawamura's research focuses on the molecular mechanisms of histone lysine demethylases and their role in epigenetic regulation. Her work explores the inhibition of 2-oxoglutarate-dependent oxygenases, including histone demethylases, and investigates the impact of oncometabolites such as 2-hydroxyglutarate on histone modifications. Kawamura also examines the therapeutic potential of histone demethylase inhibitors in cancer treatment and their effects on cellular processes like transcription and proliferation. Her studies highlight the importance of these enzymes in hypoxia and their involvement in diseases such as myeloma. Additionally, she investigates the structural and functional aspects of arylamine N-acetyltransferases and their role in drug metabolism.