Paul Schimmel

Paul Schimmel is a Professor Emeritus in the Department of Biology at the Massachusetts Institute of Technology. His research has focused on aminoacyl tRNA synthetases, with an emphasis on their role in genetic information interpretation and disease prevention. Schimmel's work includes the discovery of a 'tRNA synthetase-directed primordial' genetic code and the development of ESTs and shotgun sequencing, which were later adopted in the human genome project. His research also explores the connection between synthetases and disease, as well as their structural and functional changes in cell signaling pathways. Schimmel is affiliated with the Scripps Research Institute as a Professor of Cell and Molecular Biology.

Paul Schimmel is a Professor at The Scripps Research Institute, known for his research on aminoacyl tRNA synthetases. His work explores the structural and functional mechanisms of these enzymes, their role in translation, and their nontranslational functions. Schimmel's research interests include the recognition of transfer RNAs, the genetic code, and the connections between tRNA synthetases and disease. He has investigated how mutations in tRNA synthetases can lead to neurodegeneration and how these enzymes regulate processes such as angiogenesis. His studies also examine the potential for expanding the genetic code by incorporating nonnatural amino acids into proteins.