Amy E. Keating

Amy E. Keating is a Fellow in the Department of Biology at the Massachusetts Institute of Technology. Her research focuses on understanding how protein interaction properties are encoded in their sequences and structures. She integrates high-throughput assays, structural modeling, and bioinformatics with biochemical and biophysical experiments to study protein-protein interactions, particularly in α-helical coiled-coil proteins, Bcl-2 apoptosis-regulating proteins, and domains that bind to short linear motifs. Her work includes designing synthetic protein interactions and exploring the impact of histone mutations on chromatin and cell fate.

Amy E. Keating is a Professor of Biology and Biological Engineering at MIT, specializing in protein-protein interactions and protein design. Her research focuses on understanding the molecular mechanisms underlying coiled-coil interactions, particularly in bZIP transcription factors and BH3 peptides. She develops computational tools and experimental methods to predict and engineer protein interactions with high specificity. Her work explores how structural and sequence determinants influence binding specificity, with applications in molecular engineering and drug design. Keating's research also addresses the evolution of protein interaction networks and the design of synthetic coiled-coil interactomes for biotechnology.