Regular biography
Seychelle M. Vos is an Associate Professor of Biology at the Massachusetts Institute of Technology, affiliated with the Department of BIO. She is also recognized as an HHMI Freeman Hrabowski Scholar. Her research focuses on the interplay between gene expression and genome organization, particularly how large molecular machineries involved in genome organization and gene transcription regulate each other's function to determine cell fate and identity. She employs a range of techniques including single-particle cryo-electron microscopy, X-ray crystallography, biochemistry, and genetics to study these molecular interactions. Her work has been published in several prominent journals, including Cell and bioRxiv.
Scholar-generated biography
Seychelle Vos is an Assistant Professor in the Department of Biology at MIT, specializing in biochemistry and structural biology. Her research focuses on DNA topology, genome organization, and transcription, with an emphasis on understanding how cells manage and exploit topoisomerase function during DNA replication and transcription. She investigates the structural dynamics of transcription complexes, including the interactions between RNA polymerase II, transcription factors, and chromatin. Her work explores how transcriptional regulation is modulated by factors such as MYC, SPT5, and NELF, and how these processes contribute to gene expression and genome stability.