Jacqueline Lees

Jacqueline Lees is a Fellow at the Massachusetts Institute of Technology, affiliated with the Department of Biology. Her research focuses on identifying the proteins and pathways involved in tumorigenicity, with an emphasis on their mechanisms of action in both normal and tumor cells. She employs molecular and cellular analyses, mutant mouse models, and genetic screens in zebrafish to explore these processes. Lees' work includes studies on PRMT5 inhibitors, the PRMT5-splicing axis, and the role of BMI1 in melanocyte stem cell maintenance. Her research has been published in several scientific journals, including iScience, bioRxiv, and Pigment Cell Melanoma Res.

Jacqueline A Lees Koch is a researcher at the Koch Institute of Integrative Cancer Research at MIT, focusing on molecular mechanisms underlying cancer development and progression. Her work explores the role of transcription factors, particularly E2F family members, in cell cycle regulation and tumor suppression. She investigates how proteins like pRB and p53 interact with these factors to control cell proliferation and respond to DNA damage. Her research also examines the expression and function of PTEN, a tumor suppressor gene, in various cancers, including endometrial and breast cancers. Additionally, she studies ribosomal protein genes and their involvement in cancer, as well as the use of genome editing and organoid models to study colorectal cancer and metastasis.