Regular biography
Matthew G. Jones is an Assistant Professor of Biology at the Massachusetts Institute of Technology, Department of Biology. His research integrates computational and technological advances to decode the molecular processes underlying spatiotemporal tumor evolution, with a focus on genomic instability and extrachromosomal DNA. The Jones Lab investigates the molecular mechanisms underlying the spatiotemporal dynamics of copy-number alterations in cancer populations, develops new computational methods to trace cellular lineages, and elucidates the principles by which tumors are organized over time. The lab integrates advances in computation and AI with multi-omic approaches, lineage tracing, and high-resolution imaging to uncover generalizable rules governing tumor progression and treatment resistance.