Gottfried Otting

Prof. Gottfried Otting is an Emeritus Professor at The Australian National University, affiliated with the Department of CHEM. His research focuses on the development of NMR methods for drug development, particularly through the use of site-specifically attached paramagnetic tags employing unnatural amino acids to identify binding sites, orientations, and structures of low-molecular weight compounds on protein targets in solution. This strategy is currently being established as a tool for fragment-based drug design. The same tags are also used to monitor proteins 'in action' and determine protein interactions.

Gottfried Otting is a Professor of Structural Biology at The Australian National University, specializing in NMR spectroscopy, structural biology, and cell-free protein synthesis. His research focuses on elucidating the structural and dynamic properties of biological macromolecules using advanced NMR techniques. Otting's work includes studies on protein-DNA interactions, protein hydration, and the structural characterization of homeodomains and other DNA-binding domains. His publications explore topics such as nuclear magnetic resonance assignments, solvent suppression methods, and the dynamics of protein hydration. His research contributes to understanding molecular recognition and conformational changes in biological systems.