Yisong Alex Guo

Yisong Alex Guo is a Professor in the Department of Chemistry at Carnegie Mellon University. His research focuses on bioinorganic, bio- and bio-inspired catalysis, biophysical spectroscopy, and the study of metalloproteins. Utilizing advanced spectroscopic methods such as Mössbauer, EPR, and NRVS, along with DFT calculations, his work explores the electronic and geometric properties of iron centers in enzymes involved in critical biological processes. Guo's research aims to advance catalytic design for energy and health applications. His academic profile is available at https://www.cmu.edu/chemistry/people/faculty/guo.html, and he can be contacted at ysguo@andrew.cmu.edu.

Yisong Guo is a researcher in bioinorganic chemistry with a focus on spectroscopy, kinetics, and enzymology. His work explores the structure and reactivity of non-heme iron enzymes, particularly those involved in oxidation and hydrogenation reactions. Guo's research includes the characterization of high-spin oxoiron (IV) complexes, their self-decay pathways, and their role in catalytic processes such as C–H bond cleavage and oxygen atom transfer. His studies also involve the identification of iron-hydride intermediates in [FeFe]-hydrogenase and the elucidation of mechanisms in biosynthetic pathways like carbapenem antibiotic production. Guo's research combines experimental and computational approaches to understand the reactivity of iron centers in biological systems.