C. Joel McManus

C. Joel McManus is an Associate Professor in the Department of Biological Sciences at Carnegie Mellon University. His research focuses on genomics, the evolution of gene expression, and RNA structural biology. Specifically, his work explores how variation in gene expression contributes to phenotypic diversity and disease, with an emphasis on mechanisms regulating mRNA translation in fungal species. The McManus lab develops high-throughput assay systems to identify RNA cis-regulatory elements and structures, and employs computational methods to model their impact on mRNA translation. His research also investigates how translational control influences the virulence of fungal pathogens such as Candida albicans during infection.

Joel McManus is an Associate Professor of Biological Sciences at Carnegie Mellon University, specializing in alternative splicing, translation, and evolution. His research explores the molecular mechanisms underlying gene regulation, including the role of RNA structure in alternative splicing and the dynamics of gene expression through post-transcriptional processes. Using high-throughput sequencing technologies, he investigates how regulatory divergence and RNA structure influence evolutionary changes in gene expression. His work also examines the functional significance of non-coding RNAs and the impact of alternative splicing on protein diversity. By integrating computational and experimental approaches, McManus seeks to uncover the genetic and molecular basis of regulatory evolution in diverse organisms.