Irene Kaplow

Irene Kaplow is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University. Her research focuses on comparative genomics, transcriptional regulation, and computational biology, with an emphasis on understanding the transcriptional regulatory mechanisms underlying the evolution of mammalian phenotypes. She has contributed to the Zoonomia Consortium, which analyzes hundreds of mammalian genomes to explore evolutionary constraints and innovations. Her work includes developing computational frameworks to link enhancer activity differences across species with phenotypic evolution and applying machine learning to study complex traits. Kaplow's research also involves designing experiments to validate hypotheses and improving computational methods for regulatory analysis.

Irene M. Kaplow is a Postdoctoral Fellow at Carnegie Mellon University, with research interests in Genomics, Gene Expression Evolution, and Transcriptional Regulatory Mechanisms. Her work explores evolutionary constraint and innovation in placental mammals, focusing on the genomic timescale of mammalian evolution and the functional impacts of genetic variation. She investigates cis-regulatory elements, transcription factor binding sites, and the role of non-coding elements in human disease. Her research also integrates machine learning and functional genomic screens to understand the relationship between genetic variation and complex phenotypes. Kaplow's studies highlight the importance of regulatory elements in evolutionary processes and their implications for human health.