Jonathan Henninger

Jonathan Henninger is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University. His research focuses on RNA-directed control of transcription and cell fate in health and disease, including the study of biomolecular condensates, RNA biology and therapeutics, mammalian gene expression, and molecular biology and cellular engineering. His work integrates molecular biology, soft-matter physics, and super-resolution imaging to explore how RNA regulates genes and contributes to cell fate. Henninger's lab aims to uncover fundamental mechanisms of gene control and develop RNA-based therapies. His lab website provides additional information about his research and activities.

Jonathan Henninger's research focuses on biomolecular condensates, RNA, and gene regulation, exploring how these elements interact to control cellular processes. His work investigates the role of RNA in forming and regulating transcriptional condensates, the impact of RNA-mediated feedback on transcriptional dynamics, and the involvement of condensates in disease mechanisms such as neurodevelopmental disorders and cancer. Henninger's studies also examine how transcription factors and cofactors influence gene expression through RNA interactions and how condensates contribute to cellular identity and function. His research highlights the importance of RNA in shaping nuclear organization and signaling pathways.