Sam Hay

Sam Hay is Professor of Biophysical Chemistry in the Department of Chemistry at The University of Manchester. His research focuses on the role of protein dynamics and quantum mechanics in enzyme catalysis, using computational and theoretical approaches. He is interested in how biological processes are governed by physical chemistry, including the use of proteins and enzymes as structural and functional biomaterials and sensors. His work combines molecular dynamics simulations with density functional theory models. Hay received a first class honours degree in biochemistry from the University of Otago and a PhD in biophysics from the Australian National University. He has held postdoctoral positions at Stockholm University and the University of Manchester, where he now leads research in computational and biophysical chemistry.

Sam Hay is a Professor of Biophysical Chemistry at the University of Manchester, specializing in biophysical chemistry. His research explores the mechanisms of enzyme-catalyzed reactions, focusing on quantum biology, hydrogen tunneling, and the role of vibrations in enhancing reaction rates. He investigates how structural and dynamic features of enzymes influence catalytic efficiency, particularly in processes such as dehalogenation, decarboxylation, and electron transfer. His work also examines the structural basis of catalysis in enzymes like reductases and synthases, as well as the role of cofactors in facilitating reactions. Through a combination of experimental and computational approaches, Hay's research provides insights into the interplay between molecular motion, quantum effects, and enzymatic function.