Regular biography
Professor Dominic Campopiano is a member of the Chemistry department at The University of Edinburgh. His research focuses on natural product biosynthesis, enzymology, protein structure, antibiotics, innate immunity, and enzyme inhibitors. His work includes the study of sphingolipid biosynthesis, particularly the structure and function of Serine palmitoyltransferase (SPT), and the investigation of interactions between SPT and inhibitors. He also explores protein targets involved in metabolic reactions, such as Glutathione S-Transferases (GSTs), and examines antimicrobial peptides like defensins. Additionally, he collaborates on projects related to antibiotic resistance and antimicrobial agent development.
Scholar-generated biography
Professor Dominic Campopiano at the University of Edinburgh specializes in biocatalysis, bioorganic chemistry, and the biosynthesis of natural products. His research explores enzyme mechanisms, particularly in the context of sphingolipid biosynthesis and the structural and functional analysis of enzymes such as serine palmitoyltransferase. He investigates the role of natural products in antimicrobial activity, including studies on garlic extracts and β-defensins. His work also encompasses dynamic covalent chemistry, protein-directed reactions, and the molecular basis of enzyme inhibition. Campopiano's research integrates structural biology, spectroscopy, and kinetic analysis to elucidate enzyme mechanisms and their biological significance.