Diankun YU

Diankun Yu is a faculty member in the School of Life Sciences at Tsinghua University. Yu holds a B.S. from the University of Science and Technology of China and a Ph.D. from Tulane University, U.S. Following his doctoral studies, Yu completed postdoctoral research at the University of California, San Francisco, U.S. Yu is currently an assistant professor at Tsinghua University and serves as a principal investigator at the IDG/McGovern Institute for Brain Research at Tsinghua University and the Tsinghua-Peking Joint Center for Life Sciences. His research focuses on neural development and neuroimmunology, utilizing human-based models such as brain organoids and postmortem human brains, alongside transgenic mouse models, single-cell RNA sequencing, CRISPR-Cas9 screening, and molecular/cellular biology techniques. Yu's work aims to elucidate the mechanisms of human brain development and the role of neuroimmune and neuron-glia interactions in neurodevelopmental and neurological disorders.

Diankun Yu is a researcher at Tsinghua University focusing on organoid brain development and interneuron biology. Their work explores the molecular mechanisms underlying neural development, particularly the role of microglia and interneurons in synaptic refinement and neurogenesis. Yu's research also investigates the function of transcription factors like Shox2 in regulating neuronal properties and cardiac pacemaker cell fate. Additionally, they examine the role of G-protein-coupled receptors such as ADGRG1/GPR56 in neurodevelopmental disorders and neurodegenerative diseases like Alzheimer's. Their studies highlight the interplay between genetic regulation, cellular signaling, and neural circuit formation.