Xiao, Yufeng

Xiao Yufeng is an Assistant Professor in the School of Biological Sciences at Nanyang Technological University. His research focuses on drug discovery and development through an interdisciplinary approach that integrates medicinal chemistry and chemical biology. His work involves the design and development of small molecules to modulate protein–protein interactions, with a particular emphasis on inducing targeted protein degradation, stabilization, activation, and post-translational modifications. Xiao collaborates with experts in cancer biology, immunology, and neuroscience to translate chemical innovations into therapeutic opportunities.

Yufeng Xiao is a researcher at Nanyang Technological University with a focus on developing targeted protein degradation strategies for therapeutic applications. Their work explores PROTACs (Proteolysis Targeting Chimeras) as a means to selectively degrade disease-related proteins, particularly histone deacetylases (HDACs) such as HDAC3 and HDAC8. Xiao's research also investigates the role of histone acetylation in gene regulation and its implications in cancer immunotherapy. Additionally, they have contributed to the discovery of small molecule modulators targeting HDAC6 and the development of GPR84 antagonists for ulcerative colitis. Xiao's work emphasizes the potential of targeted protein degradation in oncology and inflammatory diseases.