Regular biography
Dr. Sandip Basak is an Assistant Professor (NRF Fellow) and Assistant Chair (Safety) in the School of Biological Sciences at Nanyang Technological University. His research focuses on ligand-gated ion channels (pLGICs), employing cryo-electron microscopy, electrophysiology, and molecular dynamics simulations to study prokaryotic and eukaryotic receptors, particularly their behavior in lipid environments. His work addresses challenges in resolving transient intermediate states and explores insect olfactory receptors as potential targets for novel repellents. Dr. Basak's interdisciplinary research bridges biophysics, structural biology, and computational science to advance understanding of ion channel function and therapeutic applications.
Scholar-generated biography
Sandip Basak is an Assistant Professor specializing in Structural Biology and Cryo-EM. His research focuses on elucidating the structural mechanisms of ion channels and receptors using cryo-electron microscopy. He investigates the structural basis of drug interactions with ion channels, such as TRPV5 inhibition by econazole and 5-HT3A receptor modulation by setron. His work also explores the functional dynamics of ligand-gated channels, including glycine and serotonin receptors, in lipid environments. Additionally, he studies the structural features of ATP synthases and ABC transporters, contributing to understanding their roles in energy transmission and drug mechanisms. His research provides insights into the molecular basis of diseases and drug development.