Regular biography
Assoc. Prof. Guillaume Thibault is an Associate Professor in the School of Biological Sciences at Nanyang Technological University. His research focuses on how cells sense and respond to stress, particularly in the endoplasmic reticulum (ER). His work explores the unfolded protein response (UPR) and its role in diseases such as metabolic disorders, neurodegeneration, and aging. Using a multi-organism approach, including yeast, C. elegans, mammalian cells, and mouse models, his lab investigates ER stress responses and their implications in conditions like impaired wound healing and retinal degeneration. He also develops bioinformatic tools to identify conserved transcriptional signatures of ER stress.
Scholar-generated biography
Guillaume Thibault is an Associate Professor at Nanyang Technological University, specializing in ER Stress, Lipid Bilayer Stress, Autophagy, Host-Pathogen Interactions, and Aging. His research explores the molecular mechanisms underlying cellular stress responses, particularly how lipid bilayer stress and endoplasmic reticulum stress influence protein homeostasis and disease. Thibault's work also investigates the role of autophagy in mitigating proteotoxicity and the interplay between stress sensors like Ire1 and transcriptional programs. His studies highlight the importance of lipid homeostasis in aging and metabolic diseases, with a focus on how stress responses contribute to cellular resilience and longevity.