Liu, Chuan Fa

Professor Liu, Chuan Fa is a member of the School of Biological Sciences at Nanyang Technological University. His research focuses on biotechnology and drug discovery, employing molecular biology, cell biology, biophysics, and organic chemistry to develop tools for the discovery and design of protein-based therapeutics, particularly bioconjugates for the diagnosis and treatment of cancer and other diseases. His work includes methods for intracellular drug delivery, structure-based drug design, and the development of small molecule drugs such as anti-malaria, anti-bacterial, and anti-cancer agents. The lab also explores antimicrobial peptides and peptide-based therapeutic agents, with an emphasis on peptidic agents against mycobacterial infections and Acinetobacter baumannii.

Chuan-Fa Liu is a researcher in Chemical Biology and Drug Discovery and Biotechnology. His work focuses on the development of novel chemical methods for peptide and protein synthesis, including orthogonal coupling strategies, native chemical ligation, and thioester precursor technologies. Liu's research also explores the role of post-translational modifications, such as acetylation and methylation, in cellular processes like chromatin structure and metabolic regulation. His publications highlight the application of these modifications in therapeutic contexts, including the design of peptide-based drugs and the study of viral and cellular RNA modifications. His contributions span both fundamental biochemical mechanisms and translational applications in drug discovery.