Regular biography
Professor Julien Lescar is a member of the School of Biological Sciences at Nanyang Technological University. His research focuses on Structural Biology and Biochemistry, with an emphasis on the discovery of new therapeutics targeting infectious diseases such as malaria and RNA viruses. He also explores enzymatic bioconjugation for the development of Antibody drug conjugates for cancer therapy and tumor imaging. His work includes studies on structural validation of targets for antimalarial drugs and the engineering of SARS-CoV-2 specific antibodies.
Scholar-generated biography
Julien lescar's research focuses on the structural and functional analysis of viral proteins, particularly those involved in viral replication and entry mechanisms. His work includes the study of flavivirus envelope glycoproteins, their conformational changes during membrane fusion, and the structural characterization of viral enzymes such as RNA-dependent RNA polymerases and proteases. He has also explored the development of antiviral inhibitors targeting key viral proteins, including the NS3 protease-helicase and the NS5 methyltransferase. His research contributes to understanding viral pathogenesis and the design of therapeutic strategies against flaviviruses such as dengue, Zika, and West Nile virus.