Regular biography
Assistant Professor Choe, Young-Jun Nanyang, is affiliated with the School of Biological Sciences at Nanyang Technological University. His research focuses on cellular proteostasis, molecular chaperones, ribosome-associated quality control (RQC), protein aggregation, and phase separation. His work explores how proteostasis declines with aging and contributes to neurodegenerative and skin diseases. The Choe lab investigates molecular mechanisms that maintain protein synthesis, folding, and degradation, with an emphasis on the role of molecular chaperones in preventing protein aggregation and promoting degradation of damaged proteins. The lab also examines ribosome-associated quality control pathways that resolve errors during translation. Using molecular biology, biochemistry, and imaging approaches, the lab seeks to uncover how proteome integrity is maintained under stress conditions.
Scholar-generated biography
Young-Jun Choe is a researcher in the School of Biological Sciences at Nanyang Technological University, Singapore, focusing on protein synthesis, degradation, and aggregation. His work explores the mechanisms of protein quality control, including ribosomal quality control (RQC) machinery, its role in preventing proteotoxic stress, and the formation of protein aggregates such as amyloid fibrils. Choe's research also investigates the structural and functional implications of protein misfolding, with applications in understanding neurodegenerative diseases and cellular stress responses. His studies integrate molecular biology, biochemistry, and biophysics to elucidate the dynamics of protein aggregation and degradation pathways.