Denis Titov

Denis Titov is an Assistant Professor (Affiliated) in the Department of BIO at the University of California, Berkeley. His research focuses on computational and experimental approaches to understand human metabolic pathway regulation, aging mechanisms, and the development of genetically encoded tools for metabolic manipulation. His work explores how metabolic homeostasis emerges from enzyme activities, the molecular basis of lifespan extension through caloric restriction, and the role of intracellular bioenergetic parameters in metabolic regulation. Titov's research utilizes model organisms like C. elegans and advanced imaging techniques to investigate these questions. His lab also develops tools to manipulate metabolic parameters in living cells, aiming to advance understanding of metabolic diseases and aging.

Denis Titov's research focuses on metabolism, aging, diet & exercise, systems biology, and chemical biology. His work explores the interplay between metabolic pathways, cellular stress responses, and disease mechanisms. Key areas include the role of NAD+/NADH and NADP+/NADPH ratios in mitochondrial function, the impact of diet and exercise on cellular metabolism, and the development of genetically encoded tools to manipulate metabolic processes. His studies also investigate the effects of natural products like triptolide on transcription factors and metabolic regulation. Titov's research bridges biochemical and systems-level approaches to understand how metabolic imbalances contribute to aging and disease.