David Savage
Regular biography
David Savage is a Professor of Biochemistry at the University of California, Berkeley, in the Department of BIO. His research focuses on understanding how protein machinery, including enzymes and compartmentalization, facilitates cellular biochemistry, with a particular emphasis on photosynthetic CO2 fixation. His lab investigates the mechanisms underlying the bacterial Carbon dioxide Concentrating Mechanism (CCM), including the carboxysome, a protein organelle that enhances the activity of the enzyme Rubisco. Savage's work integrates biochemistry, molecular biology, and synthetic biology to explore CCM function and develop tools for improving photosynthetic CO2 fixation in plants. His research also includes the development of genome editing technologies and tools for protein engineering and structural analysis.
Scholar-generated biography
David F. Savage is a Professor of Molecular & Cell Biology at UC Berkeley and an Investigator at the Howard Hughes Medical Institute. His research focuses on biochemistry, protein engineering, genome editing, and photosynthesis. He explores the structural and functional mechanisms of proteins involved in carbon fixation, aquaporins, and CRISPR-based genome editing. His work includes engineering cyanobacteria for biofuel production, developing base editors, and studying the dynamics of photosynthetic systems. Savage's research integrates structural biology, enzymology, and synthetic biology to advance our understanding of biological processes and their applications in biotechnology.