Daniel Portnoy

Daniel Portnoy is a Distinguished Professor of Biochemistry at the University of California, Berkeley, affiliated with the Department of BIO. His research focuses on intracellular pathogens, particularly Listeria monocytogenes, and their interactions with mammalian hosts. His work explores the mechanisms by which these pathogens evade immune defenses, including the role of virulence factors like Listeriolysin O (LLO) and the regulation of virulence gene expression. Portnoy's lab investigates host-pathogen interactions, innate immune responses, and vaccine development. His research also examines bacterial metabolism and its impact on host immunity, with a focus on signaling molecules such as c-di-AMP and their role in pathogenesis. His studies contribute to understanding the biology of infectious diseases and potential therapeutic strategies.