Paola Picotti

Prof. Paola Picotti is a Professor in the Department of BIO at ETH Zurich. Her research focuses on Protein Misfolding and Aggregation in Cells, with an emphasis on understanding the molecular bases of protein aggregation diseases, allostery, and proteome thermostability. Her work combines mass spectrometry-based structural and chemical proteomic methods with biochemical, cell biological, and genetic approaches. The Picotti Group develops tools to monitor protein conformational changes in complex cellular environments and investigates their impact on cellular physiology and human disease.

Paola Picotti is a researcher specializing in proteomics, systems biology, protein aggregation, and mass spectrometry. Her work focuses on understanding protein structure, function, and dynamics through advanced analytical techniques. She has developed methodologies for quantitative proteomics, including selected reaction monitoring (SRM) and targeted proteomics, enabling comprehensive analysis of proteomes. Her research explores protein thermal unfolding, phosphoproteomic responses, and the role of protein aggregation in diseases such as neurodegeneration and cancer. Picotti's contributions include the creation of resources like Human SRMAtlas and phosphoPep, which support proteomic studies across species. Her work bridges systems biology with proteomics to uncover molecular mechanisms underlying cellular processes and disease.