Regular biography
Eilika Weber-Ban is a Professor in the Department of BIO at ETH Zurich. Her research focuses on Chaperone-Protease Complexes, particularly in the context of protein homeostasis in mycobacteria. She investigates large, multi-subunit degradation machines and their substrate recruitment pathways, including the ubiquitin-like modification pathway termed pupylation. Her work explores the roles of these complexes in the survival of Mycobacterium tuberculosis and related bacteria under adverse conditions. The Weber-Ban Lab employs biochemical, microbiological, and structural approaches to study these processes. The lab's website provides additional information on recent publications and group activities.
Scholar-generated biography
Eilika Weber-Ban is a Professor of Molecular Biology and Biochemistry at ETH Zurich, focusing on the molecular mechanisms of protein folding, degradation, and chaperone systems. Her research explores the structural and functional basis of chaperone-mediated protein unfolding, translocation, and proteolysis, with a particular emphasis on the Clp family of ATPases and their interactions with proteases. She investigates how bacterial ubiquitin-like modifiers, such as Pup, regulate protein degradation through post-translational modifications. Her work also examines the role of chaperone rings in protein quality control and the structural dynamics of enzyme encapsulation in bacterial nanocompartments. These studies contribute to understanding protein homeostasis across prokaryotic and eukaryotic systems.