Jacob Corn

Prof. Dr. Jacob Corn is a Professor in the Department of BIO at ETH Zurich. His research focuses on Genome Biology, with an emphasis on the mechanisms of DNA repair, hematopoietic stem cell maintenance and differentiation, and ubiquitin signaling in cellular communication. The Corn Lab develops next-generation genome editing and regulation technologies to advance fundamental biological discovery and potential therapies for human genetic diseases. His work integrates technology development, mechanistic cellular biochemistry, and translational projects to unravel complex cellular phenotypes and improve human health.

Jacob Corn is a researcher at ETH Zürich with expertise in genome editing, Cas9, protein design, protein dynamics, and ubiquitin. His work focuses on advancing genome editing technologies through the development of catalytically active and inactive CRISPR-Cas9 systems, enhancing homology-directed repair, and improving the efficiency of gene repression and activation. Corn's research also explores the design of proteins targeting specific molecular structures, such as the influenza hemagglutinin stem region. Additionally, he investigates the role of ubiquitin in mitochondrial homeostasis and the impact of CRISPR-Cas9 on DNA repair pathways. His contributions span computational modeling, nanoparticle delivery systems, and in vivo genome editing applications.