Fred Allain

Fred Allain is a Professor in the Department of BIO at ETH Zurich. His research focuses on the Structural Biology of Protein-RNA Interaction in Health and Disease, with an emphasis on understanding the molecular mechanisms underlying genetic disorders such as Spinal Muscular Atrophy (SMA), Myotonic Dystrophy (DM), and Amyotrophic Lateral Sclerosis (ALS). His lab employs Nuclear Magnetic Resonance (NMR) spectroscopy and interdisciplinary approaches to study protein-RNA complexes and their role in gene expression regulation. Since 2014, his group has been part of the SNF external page NCCR RNA & Disease, which investigates the broader role of RNA in disease.

Frederic Allain is a Professor of BioNMR whose research focuses on the structural and functional mechanisms of RNA recognition by RNA-binding proteins. His work explores how RNA-binding domains, such as RNA recognition motifs (RRMs), double-stranded RNA binding motifs (dsRBMs), and YTH domains, mediate sequence-specific interactions with RNA. His studies reveal the molecular basis of RNA recognition, splicing regulation, and the role of RNA-binding proteins in diseases like myelodysplasia and amyotrophic lateral sclerosis (ALS). By combining NMR spectroscopy with structural biology, Allain investigates the dynamic and functional aspects of RNA-protein interactions, contributing to understanding RNA metabolism and its implications in human health.