Susan Marqusee

Susan Marqusee is a Professor of Biochemistry at the University of California, Berkeley, in the Department of BIO. Her research focuses on understanding the structural and dynamic information encoded in the linear sequence of amino acids, particularly how proteins transform from one-dimensional sequences into complex three-dimensional structures that perform cellular functions. Her work explores the energy landscapes of proteins, including non-native states that influence processes like translocation, signaling, and aggregation. She employs biophysical, structural, and computational techniques to investigate these phenomena. Her research also examines the role of the unfolded state in thermostability and proteolytic susceptibility, with applications to protein misfolding and disease.

Susan Marqusee is a researcher at the University of California, Berkeley, focusing on the structural and dynamic properties of proteins and peptides. Her work explores the thermodynamics and kinetics of protein folding, including the role of secondary structures like alpha-helices, the influence of salt bridges and hydrogen bonds on stability, and the behavior of proteins under varying conditions. She investigates folding intermediates, conformational changes, and the impact of environmental factors on protein function. Her studies also extend to the structural analysis of proteins such as RNaseH and prion proteins, as well as the discovery of allosteric sites and interactions in multi-protein systems.