James Hurley

James Hurley is a Professor of Cell Biology at the University of California, Berkeley, in the Department of BIO. His research focuses on the interplay between proteins and membrane lipids, particularly how these interactions influence cell and organelle shape, disease mechanisms, and the function of pathways such as the ESCRT system and autophagy. His laboratory employs structural approaches, including cryo-electron microscopy and biochemical methods, to investigate membrane remodeling processes and their roles in cellular functions and pathogen interactions. Hurley's work also explores the structural and mechanistic basis of how pathogens like HIV-1 subvert these processes. His research has significant implications for understanding and treating diseases such as neurodegeneration and cancer.

James Hurley is a Professor of Molecular and Cell Biology at UC Berkeley, specializing in membranes, structural biology, lysosomes, endosomes, and autophagy. His research focuses on the molecular mechanisms underlying membrane trafficking and the function of ESCRT complexes in processes such as multivesicular body biogenesis, membrane scission, and endosomal sorting. He has extensively studied the structural and functional roles of ubiquitin-binding domains, C1 domains, and other protein motifs in cellular processes. His work also explores the dynamics of ESCRT machinery during cytokinesis and its role in abscission. Hurley's research provides critical insights into the structural basis of membrane trafficking and its implications in cellular function.