Lin He

Lin He is a Professor of Cell Biology at the University of California, Berkeley, affiliated with the Department of BIO. His research focuses on the unique biological functions and molecular regulation of non-coding RNAs in development and disease. He has identified some of the first miRNAs in key oncogene and tumor suppressor pathways and has extended his work to understand the distinct biological functions and molecular regulation conferred by miRNAs and other non-coding elements using an interdisciplinary approach. His lab has provided important insights into the molecular mechanisms governing the functional complexity of the non-coding genome. He is also known for developing the CRISPR-EZ method for efficient mouse genome editing.

Lin He is a researcher at the University of California, Berkeley, focusing on microRNAs, cancer, stem cell biology, retrotransposons, and development. Their work explores the regulatory roles of microRNAs in gene expression, particularly in cancer suppression and stem cell reprogramming. Lin's research includes the investigation of microRNA clusters, such as miR-17-92 and miR-34, in tumor suppression and immune responses. They also examine the interaction between microRNAs and pathways like p53 and Sonic Hedgehog, which are critical in cancer and development. Additionally, Lin studies the impact of microRNAs on cellular reprogramming and the role of retrotransposons in genomic regulation.