Gary Firestone

Gary Firestone is a Professor of the Graduate School at the University of California, Berkeley, affiliated with the Department of BIO. His research focuses on characterizing cell signaling pathways that inhibit the uncontrolled growth of epithelial-derived tumor cells and developing preclinical strategies for anti-cancer therapeutics. His work employs molecular, biochemical, cell biological, and physiological approaches to explore how extracellular signals regulate cancer cell behavior. Firestone's research includes studies on phytochemicals like indole-3-carbinol and its derivatives, as well as natural compounds such as artemisinin, to understand their anti-cancer mechanisms. He also investigates the role of glucocorticoids in tight junction formation and cell polarity in mammary epithelial tumor cells.

Gary L Firestone is a researcher at the University of California, Berkeley, focusing on molecular and cell signaling pathways, cancer biology, and receptor biology. His work explores the mechanisms by which signaling pathways regulate cellular processes, particularly in the context of cancer progression and treatment. Firestone's research includes the study of how hormones and growth factors influence cell cycle regulation and apoptosis, with a focus on breast and prostate cancers. His publications highlight the role of proteins such as SGK, ENaC, and estrogen receptor β in cancer biology and signaling. He also investigates the potential of plant-derived compounds like 3, 3′-diindolylmethane (DIM) and artemisinin in cancer prevention and treatment.